Department of Chemistry

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Incidence and antibiotic resistance pattern of E.coli in different clinical specimens
(University of Management and Technology Lahore, 2016) Sidra Marium
Antibiotic drug resistance is a major public problem which leads to the ban on many antibiotics. The objective of the present study was to determine the incidence and antibiotic resistance pattern of E.coli in different clinical specimens. 800 samples of urine, tracheal secretion, wound and blood were collected. The microbe identification was carried out by using standard method. The antibiotic resistance pattern of E.coli were determined through Disk diffusion method. The result showed the maximum incidence of E.coli was observed in urinary tract infection. The maximum antibiotic resistance was observed for cefixime 90% followed by co-trimaxazole 89.6%, ciprofloxacin 85.7%, ceftriaxone 84.2%, ceftaidime 80.3%, amoxicillin+clav 73.2%, tobramycin 44%, pipercillin+tazob 20%, imipenam 12.6% and amikacin 122.2%. Maximum sensitivity was showed by amikacin 87.7% and imipenam 87.3%, cefoprazone+sul 84.6%, pipercillin+tazob 80%, tobramycin 55.2%. This study showed that single antibiotic showed different resistance pattern according to different sites of infection. This proved that single antibiotic cannot be used for different infection sites. The incidence pattern of E.coli was changing according to time period. E.coli changing resistance pattern is need to be addressed.