Department of Chemistry

Permanent URI for this collection

https://escholar.umt.edu.pk/handle/123456789/2021

Browse

Browsing Department of Chemistry by Subject "Amoxicillin, antitumor agents, enzyme inhibitors"

Now showing 1 - 1 of 1
  • Thumbnail Image
    Item
    Synthesis, Characterization and Biological Applications of Amoxicillin Trihydrate Complexes with Copper (Ii), Iron (Ii), Manganese (Ii)
    (University of Management & Technology, 2016) Shoukat, Samia
    Diseases are the challenge for human being as old as man himself. In every era of life people try to overcome and cure these diseases. For that purpose plants are the natural resources of drugs which are produced during different process of life as by-product. Amoxicillin is an antibiotic drug of class penicillin. The first Amoxicillin became presented in 1972. On the World Health Organization's List of Essential Medicines, it is the most important medications needed in a basic health system. One of the most commonly prescribed antibiotics in children. Amoxicillin is available as a generic medication. It is usually the drug of choice within the class because it is better-absorbed, following oral administration, than other β-lactam antibiotics. This drug acts by inhibiting the synthesis of bacterial cell walls. It inhibits cross-linkage between the linear peptidoglycan polymer chains that make up basic component of the cell walls of both Gram-positive and Gram-negative bacteria. Amoxicillin has three ionisable groups in the physiological range i.e. amino group, amide carbonyl group and the carboxyl group. Amoxicillinis active with both gram positive and gram negative bacteria. The lactam ring inhibits bacterial growth by proteolysis mechanism. This antibiotic used to treat bacterial infections caused by microorganisms. Amoxicillin degraded its β-lactam ring and produced clavulanic acid to increase its susceptibility in the presence of β-lactamase. Amoxicillin is a very popular, safe antibiotic. Copper come from its ability to control the growth of organisms. This occurs when copper is biologically available in required concentration. Copper has been established to be an effective antibacterial, antiplaque agent in mouthwashes and toothpastes. Copper also continues to be widely used for the control of unwanted organisms in fish farming (Chain, 1940). Copper antifouling agents used on fish net pens.Copper is stemming from their potential use as antimicrobial, antiviral, anti-inflammatory, antitumor agents, enzyme inhibitors or chemical nucleases. The biochemical action of copper complexes with anti-Bacterial drugs has been studied. Numerous copper showing greater anti-inflammatory activity, as well as reduced toxicity compared to the uncomplexed drug, have been prepared and structurally characterized. Copper also helpful in the design and production of antiviral and antibacterial materials, able to deactivate viruses and antibiotic-resistant bacteria.