Synthesis of N-(Un)Substituted-N-(2-Methoxyphenyl/Phenyl)-4-Chlorobenzenesulfonamides as Potent Antibacterial Derivatives
Loading...
Date
2014
Journal Title
Journal ISSN
Volume Title
Publisher
Asian Journal of Chemistry
Abstract
Sulfonamides belong to a biologically dynamic class of compounds with considerable importance for organic synthetic chemists. In the presented work, a benign series of chlorinated sulfonamides, 3a-b, was synthesized by coupling alkoxy (un) substituted anilines, 2a-b, with 4-chlorobenzenesulfonyl chloride (1) under basic pH control in an aqueous medium. The sulfonamides, 3a-b, were geared up with alkyl/aralkyl halides, 4-6, in a basic aprotic solvent to yield the target molecules, 7a-b, 8a-b and 9a-b. The structures of all the derivatives were furnished by 1H NMR, IR and EI-MS spectral analysis. All the synthesized compounds were screened for -chemotrypsin and antibacterial activities.
Description
Keywords
Substituted anilines, 4-Chlorobenzenesulfonyl chloride, Enzyme inhibition study
Citation
35. Aziz-ur-Rehman, Abbasi, M. A., Nadeem, S., Rashid, T., Ahmed, N., Irshad, M., & Rubab, K. (2014). Synthesis of N-(Un)Substituted-N-(2-Methoxyphenyl/Phenyl)-4-Chlorobenzenesulfonamides as Potent Antibacterial Derivatives. Asian Journal of Chemistry, 27(1), 71-74.