Synthesis of N-(Un)Substituted-N-(2-Methoxyphenyl/Phenyl)-4-Chlorobenzenesulfonamides as Potent Antibacterial Derivatives

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dc.contributor.authorAziz-ur-Rehman
dc.contributor.authorAthar Abbasi, Muhammad
dc.contributor.authorSohail Nadeem
dc.contributor.authorTahir Rasheed
dc.contributor.authorNaeem Ahmad
dc.contributor.authorMisbah Irshad
dc.contributor.authorKaniz Rubab
dc.date.accessioned2015-03-06T12:55:10Z
dc.date.available2015-03-06T12:55:10Z
dc.date.issued2014
dc.description.abstractSulfonamides belong to a biologically dynamic class of compounds with considerable importance for organic synthetic chemists. In the presented work, a benign series of chlorinated sulfonamides, 3a-b, was synthesized by coupling alkoxy (un) substituted anilines, 2a-b, with 4-chlorobenzenesulfonyl chloride (1) under basic pH control in an aqueous medium. The sulfonamides, 3a-b, were geared up with alkyl/aralkyl halides, 4-6, in a basic aprotic solvent to yield the target molecules, 7a-b, 8a-b and 9a-b. The structures of all the derivatives were furnished by 1H NMR, IR and EI-MS spectral analysis. All the synthesized compounds were screened for -chemotrypsin and antibacterial activities.en_US
dc.identifier.citation35. Aziz-ur-Rehman, Abbasi, M. A., Nadeem, S., Rashid, T., Ahmed, N., Irshad, M., & Rubab, K. (2014). Synthesis of N-(Un)Substituted-N-(2-Methoxyphenyl/Phenyl)-4-Chlorobenzenesulfonamides as Potent Antibacterial Derivatives. Asian Journal of Chemistry, 27(1), 71-74.en_US
dc.identifier.urihttps://escholar.umt.edu.pk/handle/123456789/1449
dc.language.isoenen_US
dc.publisherAsian Journal of Chemistryen_US
dc.subjectSubstituted anilinesen_US
dc.subject4-Chlorobenzenesulfonyl chlorideen_US
dc.subjectEnzyme inhibition studyen_US
dc.titleSynthesis of N-(Un)Substituted-N-(2-Methoxyphenyl/Phenyl)-4-Chlorobenzenesulfonamides as Potent Antibacterial Derivativesen_US
dc.typeArticleen_US
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