Synthesis, characterization and biological activity study of sulfonamide derivatives of disubstituted anilines

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dc.contributor.authorYounas, Tahir
dc.date.accessioned2016-04-14T07:54:36Z
dc.date.available2016-04-14T07:54:36Z
dc.date.issued2015
dc.descriptionSupervisor: Dr. Suhail Nadeemen_US
dc.description.abstractSulfonamides due to their medicinal importance are under consideration by the researchers. Chloro substituted sulfonamide, 3a-b, has been synthesized with high yields by a single step nucleophilic substitution reaction of disubstituted anilines, 1a-b, and 4-chlorobenzenesulfonyl chloride (2) in a weak basic aqueous medium. The synthesized sulfonamides, 3a-b, were further subjected to electrophilic substitution reaction using ethyl iodide. (4), benzyl chloride. (5) and. 4-chlorobenzyl chloride. (6) in such a solvent which is polar aprotic to get N-substituted derivatives, 7a -b, 8a-b and.9a -b, respectively. The suggested structures of all the prepared molecules were characterized using IR, 1H-NMR and EIMS spectroscopic analysis.en_US
dc.identifier.urihttps://escholar.umt.edu.pk/handle/123456789/1774
dc.publisherUNIVERSITY OF MANAGEMENT AND TECHNOLOGYen_US
dc.subjectMS Thesisen_US
dc.subjectSulfonamidesen_US
dc.subjectAzomethinesen_US
dc.titleSynthesis, characterization and biological activity study of sulfonamide derivatives of disubstituted anilinesen_US
dc.typeThesisen_US
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