Synthesis, characterization and biological activity study of sulfonamide derivatives of disubstituted anilines
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Date
2015
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UNIVERSITY OF MANAGEMENT AND TECHNOLOGY
Abstract
Sulfonamides due to their medicinal importance are under consideration by the researchers. Chloro substituted sulfonamide, 3a-b, has been synthesized with high yields by a single step nucleophilic substitution reaction of disubstituted anilines, 1a-b, and 4-chlorobenzenesulfonyl chloride (2) in a weak basic aqueous medium. The synthesized sulfonamides, 3a-b, were further subjected to electrophilic substitution reaction using ethyl iodide. (4), benzyl chloride. (5) and. 4-chlorobenzyl chloride. (6) in such a solvent which is polar aprotic to get N-substituted derivatives, 7a -b, 8a-b and.9a -b, respectively. The suggested structures of all the prepared molecules were characterized using IR, 1H-NMR and EIMS spectroscopic analysis.
Description
Supervisor: Dr. Suhail Nadeem
Keywords
MS Thesis, Sulfonamides, Azomethines