Browsing by Author "Sammia Yasmin"

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    Natural Products: Bioactivity, Biochemistry, and Biological Effects in Cancer and Disease Therapy
    (Hindawi Publishing Corporation, 2013) Chang, Hsueh-Wei; Chuang, Li-Yeh; Guleria, Sanjay; Sammia Yasmin
    The drug discovery for chemoprevention and chemotherapy remains a challenge. Natural products-derived extracts and compounds are frequently reported to discover therapeutic agents for disease and cancer. The overall scenario of this special issue ofThe Scientific World Journal presents the recent advances in biological function of selected natural products for cancer and disease therapy in terms of crude extracts and components. Some studies describe the bioinformatics tool to help to investigate the field of natural products.The papers by S. Guleria et al. and C.-C. Lee et al. provide the essential oil and/or extracts of herb Zanthoxylum alatum and Zingiber officinale for its antioxidant and antimicrobial properties, respectively. O. O. Igbinosa et al. and C.-C. Lee et al. provide the animal experiments using extractsfrom Jatropha curcas (Linn) leaf and from supercritical carbon dioxide extracted ginger, respectively. Three studies (F. M. Al-Jasass and M. S. Al-Jasser, X.-W. Chen et al., and C.-Y. Lo et al.) focus on biological functions of the compounds fromSaudiArabia herbs, Chinese herbHuang Lian (Rhizoma coptidis), and fromAlpinia galangal, respectively. Further, C.- Y. Yen et al. provide the toxicological study for cardiotoxin III in growth inhibition of oral cancer. C.-Y. Lin et al. provide a review article for the chemoprevention of cytochrome P450 in oral potentially malignant disorders (OPMDs) patients in terms of betel quid metabolism. S.-S. Liang et al. introduce the novel technique for onlinemonitoring oxidative products andmetabolites of nicotine based on tandem mass spectrometry. S ome papers introduce the bioinformatics methods or resources to study or review the natural products-related studies. L. Wang et al. introduce the gene ontology (GO) network for the systems-theoretical analysis of human hepatocellular carcinoma. Y.-C. Lin et al. provide the database (TIPdb) for anticancer, antiplatelet, and antituberculosis phytochemicals from indigenous plants in Taiwan. Three papers (W.-H. Huang et al. and J.-Y. Tang et al.) provide the drug discovery for cancer and disease therapy in terms of RNA editing, alternative splicing, and long noncoding RNAs as well as the summary for their bioinformatics resources.
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    Screening of aerial parts of abutilon bidentatum for hepatoprotective activity in rabbits
    (Academic Journals, 2011-02-04) Sammia Yasmin; Akram Kashmiri, Muhammad; Kalsoom Anwar
    The objective of this investigation was to study the hepatoprotective activity of aqueous methanolic extracts of aerial parts of Abutilon bidentatum on carbon tetra chloride (CCl4) and paracetamol induced liver damage in rabbits. The extracts at different dosages, administered orally for three days, significantly decrease serum enzymes; Serum Glutamate Pyruvate Transaminase (SGPT), Serum Glutamate Oxaloacetate (SGOT), Alkaline Phosphate (ALKP), and direct bilirubin. Silymarin was used as a standard hepatoprotective agent. The biochemical observations were supplemented with histopathological examination of rabbit liver sections. The results of this study strongly indicated that aerial parts of A. bidentatum had potent hepatoprotective action against CCl4 and paracetamol induced hepatic damage in rabbits. These findings revealed A. bidentatum an indigenous plant to be a potentially valuable herb for liver diseases.