Screening of aerial parts of abutilon bidentatum for hepatoprotective activity in rabbits
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Date
2011-02-04
Journal Title
Journal ISSN
Volume Title
Publisher
Academic Journals
Abstract
The objective of this investigation was to study the hepatoprotective activity of aqueous methanolic extracts of aerial parts of Abutilon bidentatum on carbon tetra chloride (CCl4) and paracetamol induced
liver damage in rabbits. The extracts at different dosages, administered orally for three days, significantly decrease serum enzymes; Serum Glutamate Pyruvate Transaminase (SGPT), Serum Glutamate Oxaloacetate (SGOT), Alkaline Phosphate (ALKP), and direct bilirubin. Silymarin was used as a standard hepatoprotective agent. The biochemical observations were supplemented with histopathological examination of rabbit liver sections. The results of this study strongly indicated that
aerial parts of A. bidentatum had potent hepatoprotective action against CCl4 and paracetamol induced hepatic damage in rabbits. These findings revealed A. bidentatum an indigenous plant to be a
potentially valuable herb for liver diseases.
Description
Keywords
Abutilon Bidentatum, hepatoprotective Activity, Histopathology, Paracetamol
Citation
Journal of Medicinal Plants Research Vol. 5(3), pp. 349-353, 2011