Browsing by Author "Aziz-ur-Rehman"

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    Synthesis and Screening of in vitro Antibacterial and Enzyme Inhibitory Activity of N,N-disubstituted 4-Chlorobenzenesulfonamides
    (Journal of The Chemical Society of Pakistan, 2014) S. Nadeem; Aziz-ur-Rehman; M. A. Abbasi; S. Z. Siddiqui; S. Rasool; I. Ahmad; S. Afzal
    The molecules bearing azomethine group are known to possess biological activities. In the present work, the synthesis of N'-Substitutedbenzylidene-2-(2, 4-dimethylphenoxy) acetatohydrazide (5a-d) has been elaborated using 2,4-Dimethylphenol (1) as precursor. The molecule, 1, was converted to ethyl 2-(2,4-dimethylphenoxy)acetate (2) on refluxing with ethyl 2-bromoacetate in ethanol in the presence of KOH. Ethyl ester, 2, was refluxed with hydrated hydrazine (80%) in ethanol to yield 2-(2,4- dimethylphenoxy) acetohydrazide (3). The target molecules, 5a-d, were synthesized by stirring 3 with phenyl/aryl carboxaldehyde (4a-d) in methanol in the presence of glacial acetic acid. The synthesized molecules were characterized by spectral data and evaluated for antibacterial and anti-enzymatic activities.
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    Synthesis of N-(Un)Substituted-N-(2-Methoxyphenyl/Phenyl)-4-Chlorobenzenesulfonamides as Potent Antibacterial Derivatives
    (Asian Journal of Chemistry, 2014) Aziz-ur-Rehman; Athar Abbasi, Muhammad; Sohail Nadeem; Tahir Rasheed; Naeem Ahmad; Misbah Irshad; Kaniz Rubab
    Sulfonamides belong to a biologically dynamic class of compounds with considerable importance for organic synthetic chemists. In the presented work, a benign series of chlorinated sulfonamides, 3a-b, was synthesized by coupling alkoxy (un) substituted anilines, 2a-b, with 4-chlorobenzenesulfonyl chloride (1) under basic pH control in an aqueous medium. The sulfonamides, 3a-b, were geared up with alkyl/aralkyl halides, 4-6, in a basic aprotic solvent to yield the target molecules, 7a-b, 8a-b and 9a-b. The structures of all the derivatives were furnished by 1H NMR, IR and EI-MS spectral analysis. All the synthesized compounds were screened for -chemotrypsin and antibacterial activities.