Synthesis and Screening of in vitro Antibacterial and Enzyme Inhibitory Activity of N,N-disubstituted 4-Chlorobenzenesulfonamides
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Date
2014
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of The Chemical Society of Pakistan
Abstract
The molecules bearing azomethine group are known to possess biological activities. In the present work, the synthesis of N'-Substitutedbenzylidene-2-(2, 4-dimethylphenoxy) acetatohydrazide (5a-d) has been elaborated using 2,4-Dimethylphenol (1) as precursor. The molecule, 1, was converted to ethyl 2-(2,4-dimethylphenoxy)acetate (2) on refluxing with ethyl 2-bromoacetate in ethanol in the presence of KOH. Ethyl ester, 2, was refluxed with hydrated hydrazine (80%) in ethanol to yield 2-(2,4- dimethylphenoxy) acetohydrazide (3). The target molecules, 5a-d, were synthesized by stirring 3 with phenyl/aryl carboxaldehyde (4a-d) in methanol in the presence of glacial acetic acid. The synthesized molecules were characterized by spectral data and evaluated for antibacterial and anti-enzymatic activities.
Description
Keywords
Dimethylphenol, Antibacterial Activity, Anti-enzymatic Activity, Azomethine, Hydrazones
Citation
34. Aziz-ur-Rehman, Nafeesa, K., Abbasi, M. A., Nadeem, S., Khan, K. M., Ahmad, I., & Afzal, S. (2014). Synthesis and Screening of in vitro Antibacterial and Enzyme Inhibitory Activity of N,N-disubstituted 4-Chlorobenzenesulfonamides. Journal of The Chemical Society of Pakistan, 36(6).