Synthesis and Screening of in vitro Antibacterial and Enzyme Inhibitory Activity of N,N-disubstituted 4-Chlorobenzenesulfonamides

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dc.contributor.authorS. Nadeem
dc.contributor.authorAziz-ur-Rehman
dc.contributor.authorM. A. Abbasi
dc.contributor.authorS. Z. Siddiqui
dc.contributor.authorS. Rasool
dc.contributor.authorI. Ahmad
dc.contributor.authorS. Afzal
dc.date.accessioned2015-03-05T13:38:47Z
dc.date.available2015-03-05T13:38:47Z
dc.date.issued2014
dc.description.abstractThe molecules bearing azomethine group are known to possess biological activities. In the present work, the synthesis of N'-Substitutedbenzylidene-2-(2, 4-dimethylphenoxy) acetatohydrazide (5a-d) has been elaborated using 2,4-Dimethylphenol (1) as precursor. The molecule, 1, was converted to ethyl 2-(2,4-dimethylphenoxy)acetate (2) on refluxing with ethyl 2-bromoacetate in ethanol in the presence of KOH. Ethyl ester, 2, was refluxed with hydrated hydrazine (80%) in ethanol to yield 2-(2,4- dimethylphenoxy) acetohydrazide (3). The target molecules, 5a-d, were synthesized by stirring 3 with phenyl/aryl carboxaldehyde (4a-d) in methanol in the presence of glacial acetic acid. The synthesized molecules were characterized by spectral data and evaluated for antibacterial and anti-enzymatic activities.en_US
dc.identifier.citation34. Aziz-ur-Rehman, Nafeesa, K., Abbasi, M. A., Nadeem, S., Khan, K. M., Ahmad, I., & Afzal, S. (2014). Synthesis and Screening of in vitro Antibacterial and Enzyme Inhibitory Activity of N,N-disubstituted 4-Chlorobenzenesulfonamides. Journal of The Chemical Society of Pakistan, 36(6).en_US
dc.identifier.urihttps://escholar.umt.edu.pk/handle/123456789/1425
dc.language.isoenen_US
dc.publisherJournal of The Chemical Society of Pakistanen_US
dc.subjectDimethylphenolen_US
dc.subjectAntibacterial Activityen_US
dc.subjectAnti-enzymatic Activityen_US
dc.subjectAzomethineen_US
dc.subjectHydrazonesen_US
dc.titleSynthesis and Screening of in vitro Antibacterial and Enzyme Inhibitory Activity of N,N-disubstituted 4-Chlorobenzenesulfonamidesen_US
dc.typeArticleen_US
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