2016

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Synthesis, Spectroscopic Characterization & Biological Screening of Co(II), Cr(III), Ag(I) Complexes with Amoxicillin
(UMT.Lahore, 2016) ANUM SHARIF
The bacteria and fungi are getting resistant against antibiotic drugs. There is need to search for new compounds and coordination complexes of biologically significant molecules that are resistant against pathogens. Amoxicillin is very famous and harmless antibiotic and it is good absorber as compared to other beta-lactam antibiotics. It is used to treat many different types of infections caused by susceptible microorganisms. It works against Gram‐negative bacteria more effectively as compare to Gram positive bacteria. In many areas of research amoxicillin and its derivatives are frequently used especially in pharmaceutical and biological studies. Amoxicillin is bio functional active due to the presence of lactam ring this ring protects from bacterial growth by the mechanism of petrolysis. Amoxicillin is unstable in acidic medium it needs to be stabilized for better anti-microbial effect. Amoxicillin can be stabilized by making complexes with different metals. Metal complexes have great biological importance. It works in biological catalytic reactions, antimicrobial agents, in industries and herbicides. Chelating ligands that contains heteroatoms such as S, O and N show great resistance against disease causing microorganisms and are important due to their different ways of coordination with metal ions.