Synthesis, Spectroscopic Characterization & Biological Screening of Co(II), Cr(III), Ag(I) Complexes with Amoxicillin
Loading...
Date
2016
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
UMT.Lahore
Abstract
The bacteria and fungi are getting resistant against antibiotic drugs. There is need to
search for new compounds and coordination complexes of biologically significant
molecules that are resistant against pathogens. Amoxicillin is very famous and
harmless antibiotic and it is good absorber as compared to other beta-lactam
antibiotics. It is used to treat many different types of infections caused by susceptible
microorganisms. It works against Gram‐negative bacteria more effectively as compare
to Gram positive bacteria. In many areas of research amoxicillin and its derivatives
are frequently used especially in pharmaceutical and biological studies. Amoxicillin is
bio functional active due to the presence of lactam ring this ring protects from
bacterial growth by the mechanism of petrolysis. Amoxicillin is unstable in acidic
medium it needs to be stabilized for better anti-microbial effect. Amoxicillin can be
stabilized by making complexes with different metals. Metal complexes have great
biological importance. It works in biological catalytic reactions, antimicrobial agents,
in industries and herbicides. Chelating ligands that contains heteroatoms such as S, O
and N show great resistance against disease causing microorganisms and are
important due to their different ways of coordination with metal ions.