2021

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Browsing 2021 by Author "SADAF ASHRAF"

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    ANTIMICROBIAL STUDY OF TURMERIC PHYTOCHEMICALS
    (UMT.Lahore, 2021) SADAF ASHRAF; WARDA FAROOQ
    There is currently a lot of research on discovering various drugs from natural products such as plants. For many years, medicinal plants such as turmeric have been used as a home remedy for inflammation, anti-cancer, and infectious disease treatment. Turmeric is found in Curcuma longa's underground rhizome. It contains a variety of bioactive compounds such as flavonoids, volatile oils, zingiberene, carbohydrates, resins, and curcumin, which are used to improve physical activity. The antimicrobial properties of Curcuma longa have been analyzed by Pubchem, SwissADME, and protox were determined for immunotoxicity, cytotoxicity, mutagenicity, and carcinogenicity. In Molecular docking, computational tools such as Protein Data Bank (PDB), Chimera, Discovery Studio, and Autodock Vina were used. By reducing the number of experiments, in silico models help in better understanding the chemical and physical processes of turmeric as a drug. Three out of sixty-three phytochemicals fulfilled the requirement and docked with the anti bacterial protein against Escherichia coli to obtain their active site residues, binding affinities, and the number of hydrogen bonds. The hydrogen bond and binding affinity values of Ascorbic acid, bisdemethoxycurcumin, and eugenol are to be 8, 7, 5, and -5.9, -7.6,-5.7 kcal/mol, respectively. The docking result confirmed that these ligands have the potential to be used as medicine to treat microbial diseases caused by Escherichia coli.