ANTIMICROBIAL STUDY OF TURMERIC PHYTOCHEMICALS
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Date
2021
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Journal ISSN
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Publisher
UMT.Lahore
Abstract
There is currently a lot of research on discovering various drugs from natural
products such as plants. For many years, medicinal plants such as turmeric have been
used as a home remedy for inflammation, anti-cancer, and infectious disease
treatment. Turmeric is found in Curcuma longa's underground rhizome. It contains a
variety of bioactive compounds such as flavonoids, volatile oils, zingiberene,
carbohydrates, resins, and curcumin, which are used to improve physical activity.
The antimicrobial properties of Curcuma longa have been analyzed by Pubchem,
SwissADME, and protox were determined for immunotoxicity, cytotoxicity,
mutagenicity, and carcinogenicity. In Molecular docking, computational tools such
as Protein Data Bank (PDB), Chimera, Discovery Studio, and Autodock Vina were
used. By reducing the number of experiments, in silico models help in better
understanding the chemical and physical processes of turmeric as a drug. Three out
of sixty-three phytochemicals fulfilled the requirement and docked with the anti bacterial protein against Escherichia coli to obtain their active site residues, binding
affinities, and the number of hydrogen bonds. The hydrogen bond and binding
affinity values of Ascorbic acid, bisdemethoxycurcumin, and eugenol are to be 8, 7,
5, and -5.9, -7.6,-5.7 kcal/mol, respectively. The docking result confirmed that these
ligands have the potential to be used as medicine to treat microbial diseases caused
by Escherichia coli.