Hypoglycemic activity of pistachia khinjuk
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Date
2017
Authors
Journal Title
Journal ISSN
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Publisher
University of Management & Technology
Abstract
Diabetes is spreading all over the world day by day. There are many ways to treat diabetes
mellitus which includes synthetic drugs, Homeopathic medicine or Unani Medicine etc. These
Medicines have many side effects. Natural products include herbs, shrubs and large plants which
cure diabetes mellitus and prove excellent hypoglycemic activity. These herbal medicines have
no side effects. Almost all the species of family Anacardiaceae show hypoglycemic activity and
used from centuries to cure diabetes. Many pistachio species show hypoglycemic activity and
have a very long history of herbal remedies. The present study evaluates the hypoglycemic effect
of Pistachia khinjuk. In this study, hypoglycemic effect is checked from the extract and wax of
Pistachia khinjuk individually. Six groups of Swiss albino mice were made for wax and six for
extract (80:20 Methanol: water) of Pistachia khinjuk separately and each group contains six
albino mice. All the mice were injected alloxan monohydrate except normal group of wax and
extract. Group 1 was treated as normal group and receives no treatment, group 2 receive 5mg/kg
of glibenclamide after alloxan monohydrate induction, group 3 receive no treatment after alloxan
monohydrate induction, group 4 and 5 receive 500 and 250mg/kg of Pistachia khinjuk extract
while group 6 receives 500mg/kg Pistachia khinjuk wax after alloxan monohydrate treatment.
Almost all the mice for wax (Pistachia khinjuk) of group 4, 5 and 6 show gradual increase in
their diabetes while all the mice for extract (Pistachia khinjuk) of group 4, 5 and 6 show
hypoglycemic activity and decreases blood glucose level. Present study indicated the
hypoglycemic effect of Pistachia khinjuk for extract but indicates opposite results for wax of
Pistachia khinjuk. There is a clear difference of increased blood glucose level for wax of
Pistachia khinjuk. There may be many factors behind this activity which needs more research on
it by detecting and analyzing specific compound which cause this effect. The methanolic extract
due to phenolic constituents proves to be excellent antidiabetic medicine.
Description
Supervised by: DR. Sammia Shahid
Keywords
Homeopathic medicine, Diabetes, Pistachia khinjuk,, Mphil