A biochemical analysis of detrimental effects of covid-19 severity on multiple organ system
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Date
2022
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Publisher
UMT, Lhr
Abstract
A worldwide health hazard is the coronavirus disease epidemic of 2019 (COVID 19). Although abrupt respiratory failure and diffuse alveolar injury were the main features of COVID-19, other organ involvement like liver, kidney and blood parameters needs to be considered. When individuals with COVID-19 have liver and renal injury, it makes attaining the appropriate dose of medications more difficult and increases the likelihood of severe drug reactions. As a result, monitoring liver and kidney functions in COVID-19 patients on meticulous basis leads to early detection of liver and kidney diseases, as well as attaining appropriate therapeutic doses and lowering the risk of adverse medication reactions. There is still a lack of information regarding the prevalence and clinical significance of liver injury, renal injury and CBC alterations in COVID- 19 patients from regions with low mortality and severity rates. The aim of this study is to report the incidence of above-mentioned parameters, characterize the changes in these parameters during the disease, and assess the relationship between them in this cohort of 354 confirmed COVID-19 patients including 198 males and 156 females in Lahore. The statistical analysis including Chi square and T test is applied to evaluate the hypothesis. Out of all parameters the RBC in normal patients, PLT in normal patients, ALT in normal, moderate and severe patients, AST in moderate patients and Creatinine in moderate Covid-19 patients give significant results. It is concluded that the biochemical parameters are affected by the Covid-19 and this information plays crucial role in the evaluation of disease severity, its progression and effect on other body organs in the COVID patients. It also helps in the disease management and preventing the severe illness and serious health issues including renal failure and liver damage.