Synthesis and biological screening of some azomethine derivatives of 2,4-dimethylcarbolic acid
| dc.contributor.author | Ata Ur Rehman | |
| dc.date.accessioned | 2016-04-22T07:47:20Z | |
| dc.date.available | 2016-04-22T07:47:20Z | |
| dc.date.issued | 2015 | |
| dc.description | Supervisor: Dr. Sohail Nadeem | en_US |
| dc.description.abstract | The molecules comprising azomethine group are famous to possess biological activities. In the present work, the synthesis of N'-Substitutedbenzylidene-2-(2,4-dimethylphenoxy) acetohydrazide (5a-d) has been performed using 2,4-Dimethylphenol(1) as precursor. The molecule 1, was transformed into ethyl 2-(2,4-dimethylphenoxy)acetate (2) on refluxing with ethyl 2-bromoacetate in ethanol medium in the presence of base KOH. Ethyl ester 2, was refluxed with hydrated hydrazine (80%) in ethanol medium to produce 2-(2,4-dimethylphenoxy) acetohydrazide (3). The target molecules 5a-d, were manufactured by stirring 3 with phenyl/aryl carboxaldehyde (4a-d) in methanol medium in the presence of glacial acetic acid. The synthesized molecules were characterized by physical spectral data and estimated for antibacterial and anti-enzymatic activities. | en_US |
| dc.identifier.uri | https://escholar.umt.edu.pk/handle/123456789/1881 | |
| dc.publisher | UNIVERSITY OF MANAGEMENT AND TECHNOLOGY | en_US |
| dc.subject | MS Thesis | en_US |
| dc.subject | Azomethine derivatives | en_US |
| dc.subject | 2,4-dimethylcarbolic acid | en_US |
| dc.title | Synthesis and biological screening of some azomethine derivatives of 2,4-dimethylcarbolic acid | en_US |
| dc.title | Synthesis and biological screening of some azomethine derivatives of 2,4-dimethylcarbolic acid | en_us |
| dc.type | Thesis | en_US |
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