SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL APPLICATIONS OF AMOXICILLIN TRIHYDRATE COMPLEXES WITH COPPER (II), IRON (II), MANGANESE (II)
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Date
2016
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Publisher
UMT.Lahore
Abstract
Diseases are the challenge for human being as old as man himself. In every era of life
people try to overcome and cure these diseases. For that purpose plants are the natural
resources of drugs which are produced during different process of life as by-product.
Amoxicillin is an antibiotic drug of class penicillin. The first Amoxicillin became
presented in 1972. On the World Health Organization's List of Essential Medicines, it
is the most important medications needed in a basic health system. One of the most
commonly prescribed antibiotics in children. Amoxicillin is available as a generic
medication. It is usually the drug of choice within the class because it is better-absorbed,
following oral administration, than other β-lactam antibiotics. This drug acts by
inhibiting the synthesis of bacterial cell walls. It inhibits cross-linkage between the
linear peptidoglycan polymer chains that make up basic component of the cell walls of
both Gram-positive and Gram-negative bacteria. Amoxicillin has three ionisable groups
in the physiological range i.e. amino group, amide carbonyl group and the carboxyl
group. Amoxicillinis active with both gram positive and gram negative bacteria. The
lactam ring inhibits bacterial growth by proteolysis mechanism. This antibiotic used to
treat bacterial infections caused by microorganisms.