Hepatoprotective activity of pistachia khinjuk

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dc.contributor.authorTayyaba Mushtaq
dc.date.accessioned2018-02-08T10:57:25Z
dc.date.available2018-02-08T10:57:25Z
dc.date.issued2017
dc.descriptionSupervised by: Dr. Sammia Shahiden_US
dc.description.abstractThe present investigations were carried out to establish the medicinal value of Pistachia khinjuk synonym Shiney. This medicinal plant belongs to the family Anacardiaceae (cashews) including more than 700 species of 82 generas. Pistachia is widely distributed in the Mediterranean region. Pistacia khinjuk can grow up to 25 meters in length and thrive in arid and semi-arid areas. In this research the objective was to test the hepatoprotective activity by the induction of CCl4 to the Swiss Albino Mice. The seeds extract in different doses 100 mg/kg, 250 mg/kg, 500 mg/kg were given orally to albino mice groups, each group contained six mice. The dose was given for fourteen days and on 15th day a healthy mouse of each group was dissected blood was taken in EDTA tubes and liver was preserved in Formalin solution. The blood was tested by ALTs kit. It was observed that the levels of serum enzymes such as Serum Glutamate Oxaloacetate transaminase (SGOT), Alkaline Phosphate (ALKP), Serum Glutamate Pyruvate Transaminase (SGPT), and bilirubin levels were decreased. For the purpose of comparative study silymarin was used as a standard drug. The results revealed that , the values of SGOT, SGPT, ALKP and Bilirubin were 61.05, 57.55, 138.31, 0.91 for positive control group, 85.48, 55.29, 138.31, 0.46 for negative control group, 119.99, 107.09, 151.96, 1.43 for P.khinjuk group (100 mg/kg), 89.89, 94.41, 191.46, 1.09 for P.khinjuk group (250 mg/kg) and 69.47, 72.21, 164.35, 0.79 for P.khinjuk group (500 mg/kg) repectively. The histopathological studies of mice liver were carried out . The histopathology study showed that the plant extract of 100mg/kg showed less positive effect rather than 250 mg/kg and 500 mg/kg showed high and positive effect than other concentrations(100 mg/kg, 250 mg/kg) against CCl4 damage. The results of this study on the seed extract of Pistacia khinjuk confirmed excellent hepatoprotective activity against CCl4 damaged liver in albino mice. This study proved that Pistacia khinjuk acts as an indigenous plant which is highly effective plant for the liver diseases. In future further work is required to isolate chemical and biological constituents from the seeds and to check biological activity of purified constituentsen_US
dc.identifier.urihttps://escholar.umt.edu.pk/handle/123456789/2654
dc.language.isoenen_US
dc.publisherUniversity of Management and Technologen_US
dc.subjectPistachia khinjuken_US
dc.subjectSerum Glutamate Oxaloacetateen_US
dc.subjectMS thesisen_US
dc.titleHepatoprotective activity of pistachia khinjuken_US
dc.titleHepatoprotective activity of pistachia khinjuken_us
dc.typeThesisen_US
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