Epitope Mapping of HCV Structural Proteins for Potential Vaccine Design; an Insilico Approach

Simple item page
dc.contributor.authorMunir, Sania
dc.date.accessioned2019-01-21T14:14:50Z
dc.date.available2019-01-21T14:14:50Z
dc.date.issued2018
dc.descriptionDr. Muhammad Sohail Afzalen_US
dc.description.abstractHepatitis C virus (HCV) is a leading cause of morbidity and mortality globally. Recent studies have shown an increased burden (2.8%) of HCV infection, which is nearly equal to 185 million infections globally. Highest prevalence rated countries are located in Asia and Africa. Pakistan has the high HCV seroprevalence rates between 2.4% and 6.5% in general population. Due to error prone nature, HCV has the ability to escape immune system surveillance. High variation in genome is the primary hurdle in vaccine development against the virus. After the infection host, Cytotoxic T- lymphocytes contribute their role in the eradication of infection. For successful eradication of HCV a vaccine development is a need of the hour. HCV Structural proteins are one of the potential immunogenic viral proteins. The study is aimed to analyze the core, E1 and E2 protein as a potential vaccine candidate. In this study the sequences of HCV structural proteins were taken and comparison was made by BLASTP to find out maximum potential candidates for a vaccine development. All the sequences were aligned by using CLUSTAL OMEGA software and consensus sequence was developed by using JALVIEW software. Immune Epitope Database (IEDB) was used to predict epitope sequences. The predicted epitopes were analyzed to determine their antigenicity through Vaxijen server version 2.0. I- Tasser software further used for the visualization of predicted epitopes positions and immunogenicity.en_US
dc.identifier.urihttps://escholar.umt.edu.pk/handle/123456789/3585
dc.language.isoenen_US
dc.publisherUniversity of Management & Technologyen_US
dc.subjectHCV; Core protein; Immunity; Epitope; Vaccine; Insilicoen_US
dc.subjectMSen_US
dc.titleEpitope Mapping of HCV Structural Proteins for Potential Vaccine Design; an Insilico Approachen_US
dc.typeThesisen_US
Files
Original bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
Summary.pdf
Size:
153.23 KB
Format:
Adobe Portable Document Format
Description:
Download
No Thumbnail Available
Name:
full text.txt
Size:
126 B
Format:
Plain Text
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Department of Life Sciences