Co-ordination of metal ions with indole-3-acetic acid; synthesis, characterization and biological screening

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dc.contributor.authorKiran Nazia Sikandar
dc.date.accessioned2018-04-13T06:14:41Z
dc.date.available2018-04-13T06:14:41Z
dc.date.issued2017
dc.descriptionSupervised by: Dr. Khurram Shahzad Munawaren_US
dc.description.abstractMetal carboxylatesplay very important role in various biological reactions.Significance of drugs and their complexes have been desired to synthesize and characterize some ternary inner transition metals complexes with carboxylate and their derivative. In this work, five mononuclear metal complexes such as zinc, copper and vanadium have been synthesized with indole-3-acetic acid as primary ligand and 2,2'-bipyridine, 1,10-phenanthroline and 8-hydroxy quinoline as secondary ligands by reflux method. The synthesized transition metal complexes have been analyzed by FT-IR,1H-NMR, UV-Visible spectroscopy and conductance measurement. The FT-IR spectroscopy revealed that nitrogen atom of ligand does not coordinate with metal ions. The vibrational frequency of NH was not shifted to a considerable extent in complexes 3–8 as compared to the free ligand (IAA).As a result, the indole-3-acetic acid work as simple carboxylic acid ligands even in the synthesis of chelate complexes. The outcomes of 1H-NMR showed that the -COOH resonance of IAA at 12.19 ppm was absent in Na-IAA and in complexes, which suggests the replacement of the carboxylic proton by the metal moiety. The synthesized complexes have distorted tetrahedral geometry in case of zinc complex and octahedral geometry in copper and vanadium due to the attachment of co-ligands. The molar conductance data of synthesized complexes revealed that the ligand and complexes are non-electrolyte. Antibacterial screening was performed by the well diffusion method against gram negative (Klebsiella pneumoniae, Escherichia coli and Pseudomonas aeruginosa) and gram-positive (Staphlococcus aureus) bacteria. All complexes exhibited higher antimicrobial potential than ampicillin (standard reference drug). It was confirmed byinhibition zones that metal complexes are efficient antibiotic agents.en_US
dc.identifier.urihttps://escholar.umt.edu.pk/handle/123456789/2995
dc.language.isoenen_US
dc.publisherUniversity of Management and Technologen_US
dc.subjectconfirmed byinhibition zonesen_US
dc.subjectCOOH resonance of IAA at 12.19 ppmen_US
dc.subjectMS thesisen_US
dc.titleCo-ordination of metal ions with indole-3-acetic acid; synthesis, characterization and biological screeningen_US
dc.titleCo-ordination of metal ions with indole-3-acetic acid; synthesis, characterization and biological screeningen_us
dc.typeThesisen_US
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