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Browsing School of Science (SSC) by Subject "Amoxicillin dihydrate"

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    Synthesis, Spectroscopic Characterization & Biological Screening of Co(II), Cr(III), Ag(I) Complexes with Amoxicillin
    (University of Management and Technology, 2016) Sharif, Anum
    The bacteria and fungi are getting resistant against antibiotic drugs. There is need to search for new compounds and coordination complexes of biologically significant molecules that are resistant against pathogens. Amoxicillin is very famous and harmless antibiotic and it is good absorber as compared to other beta-lactam antibiotics. It is used to treat many different types of infections caused by susceptible microorganisms. It works against Gram‐negative bacteria more effectively as compare to Gram positive bacteria. In many areas of research amoxicillin and its derivatives are frequently used especially in pharmaceutical and biological studies. Amoxicillin is bio functional active due to the presence of lactam ring this ring protects from bacterial growth by the mechanism of petrolysis. Amoxicillin is unstable in acidic medium it needs to be stabilized for better anti-microbial effect. Amoxicillin can be stabilized by making complexes with different metals. Metal complexes have great biological importance. It works in biological catalytic reactions, antimicrobial agents, in industries and herbicides. Chelating ligands that contains heteroatoms such as S, O and N show great resistance against disease causing microorganisms and are important due to their different ways of coordination with metal ions. It is found that when metal is attached with biologically active specie its action against pathogens increases. Three different complexes of amoxicillin were prepared with metal (II) chromium, cobalt and silver. The sample were analyzed by IR. The antibacterial activity was also performed by agar diffusion assay to check the antibacterial effect of these complexes. The infrared spectroscopy showed that metal complex is formed by hydroxyl group. All the complexes showed resistance against Gram negative Pseudomonas, Gram positive Staphylococcus aureusand Streptococcus mutans bacteria. The zone of inhibition for silver amoxicillin against Streptococcus mutans, Pseudomonas and Staphylococcus aureus was 19mm, 18mm and 18mm respectively. Zone of inhibition measured for chromium amoxicillin dehydrate against Pseudomonas was 14 mm which is minimum as compared with other complexes.silver amoxicillin showed maximum antibacterial activity against all strain Staphylococcus aureusand Pseudomonas and Streptococcus mutans. Therefore it is concluded that chromium amoxicillin dehydrate, silver amoxicillin and cobalt amoxicillin complexes could be served as antibacterial agents.