Browsing by Author "Younas, Tahir"

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    Synthesis, characterization and biological activity study of sulfonamide derivatives of disubstituted anilines
    (UNIVERSITY OF MANAGEMENT AND TECHNOLOGY, 2015) Younas, Tahir
    Sulfonamides due to their medicinal importance are under consideration by the researchers. Chloro substituted sulfonamide, 3a-b, has been synthesized with high yields by a single step nucleophilic substitution reaction of disubstituted anilines, 1a-b, and 4-chlorobenzenesulfonyl chloride (2) in a weak basic aqueous medium. The synthesized sulfonamides, 3a-b, were further subjected to electrophilic substitution reaction using ethyl iodide. (4), benzyl chloride. (5) and. 4-chlorobenzyl chloride. (6) in such a solvent which is polar aprotic to get N-substituted derivatives, 7a -b, 8a-b and.9a -b, respectively. The suggested structures of all the prepared molecules were characterized using IR, 1H-NMR and EIMS spectroscopic analysis.