2019

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Browsing 2019 by Author "Mashal Asghar"

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    Prevalence of thrombocytopenia in patients infected with hepatitis c virus
    (UMT, Lhr, 2019) Mashal Asghar
    Hepatitis C is linked with multiple complications like cirrhosis of liver leading ultimately to hepatocellular carcinoma. One of the complication associated with HCV is thrombocytopenia. The pathogenesis of HCV linked thrombocytopenia falls under two main mechanisms which are decreased production of platelets from bone marrow and increased destruction of platelets. The aim of the study was to find the prevalence of HCV induced thrombocytopenia in local population of Pakistan. In this study total 500 samples were analyzed through PCR and positive PCR samples (420) were further analyzed for platelet count. Patients were further categorized on the basis of gender. According to this study the overall prevalence of HCV induced thrombocytopenia were 31.20%, males (37.2%) were more prone to thrombocytopenia than females (25.8%). Patients were also categorized on the basis of age and highest prevalence was seen in age group 60-80 which was 45%. Based upon the findings of this study and comparison with previous studies, it is clear that chronic HCV infection has strong association with thrombocytopenia. It is important to prevent thrombocytopenia in HCV positive patients as thrombocytopenia has serious consequences that may lead to uncontrolled bleeding. Different measures can be taken. CBC can be done on regular basis as a routine parameter to check the platelets count of these patients. Moreover, combined therapies can be given to patients in addition to anti-viral therapy so the platelets count can be maintained within normal limits. Thrombopoietin analogues can be used in case of liver cirrhosis or fibrosis as in these cases there is no or little amount of thrombopoietin produced.