2019

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Browsing 2019 by Author "FAIZA ATA"

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    Prevalence of hla (mhc) class ii alleles in punjabi population in pakistan
    (UMT,Lhr, 2019) FAIZA ATA
    Human Leucocyte antigen (HLA) complex is present on chromosome no.6 which has 200 genes, out of which 40 genes encode for leukocyte antigens. Regulation of immune system and cells differentiation is the main function of HLA. In this study, MHC class II alleles such as HLA-DRB1, HLA-DQB1 and HLA-DQA1 were identified in 216 patients and their demographic prevalence was studied with respect to gender difference, ABO type and geographical distribution in general population of Punjab. It was observed that at HLA-DRB1, allele 3 was most prevalent with 23.14% at HLA-DQB1 locus, allele 3 was most prevalent with 24.07% while at HLA-DQA1 locus, allele 1 with 43.75% frequency was the most prevalent. Then serotypes frequencies at HLA class II loci were evaluated. The observed serotypes frequencies were: DR17 (3) with 17.82% frequency at HLA-DRB1 locus and DQ2 with 30.32% frequency at HLA-DQB1 locus were most prevalent in the general population of Punjab. Then the percentage frequencies of alleles and serotypes were assessed to check their prevalence in male and female Punjab population. We found the highest percentage frequencies of allele 3 with 22.59% frequency at HLA-DRB1, allele 3 with 25.92% frequency at HLA-DQB1 and allele 1 with 44.44% frequency at HLA-DQA1 in the male population of Punjab. After male population, it was observed that in the female population allele 3 with 24.07% frequency at HLA-DRB1, allele 3 with 20.98% at HLA-DQB1 locus and allele 1 with 42.59% frequency at HLA-DQA1 is found to be most prevalent. After gender difference population data was analyzed with respect to different blood groups A +ve, A –ve, AB +ve, B +ve, B –ve, O +ve and O –ve and with respect to their geographical distribution in the population of Punjab.