2016

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Browsing 2016 by Author "UZMA NAWAZ"

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    SYNTHESIS STRUCTURAL ELUCIDATION AND ANIMICROBIAL ACTIVITIES OF ZINC, CADMIUM AND NICKEL COMPLEXES WITH AMOXICILLIN TRIHYDRATE
    (UMT.Lahore, 2016) UZMA NAWAZ
    The bacteria and fungi are getting resistant against antibiotic drugs. There is need to search for new compounds and coordination complexes of biologically significant molecules that are resistant against pathogens. Amoxicillin is very famous and harmless antibiotic and it is good absorber as compared to other beta-lactam antibiotics. It is used to treat many different types of infections caused by susceptible microorganisms. It works against Gram‐negative bacteria more effectively as compare to Gram positive bacteria. In many areas of research amoxicillin and its derivatives are frequently used especially in pharmaceutical and biological studies. Amoxicillin is bio functional active due to the presence of lactam ring this ring protects from bacterial growth by the mechanism of petrolysis. Amoxicillin is unstable in acidic medium it needs to be stabilized for better anti-microbial effect. Amoxicillin can be stabilized by making complexes with different metals. Metal complexes have great biological importance. It works in biological catalytic reactions, antimicrobial agents, in industries and herbicides. Chelating ligands that contains heteroatoms such as S, O and N show great resistance against disease causing microorganisms and are important due to their different ways of coordination with metal ions. It is found that when metal is attached with biologically active specie its action against pathogens increases. Three different complexes of amoxicillin were prepared with metal (II) cadmium, nickel and zinc. The sample were analyzed by IR. The antibacterial activity was also performed by agar diffusion assay to check the antibacterial effect of these complexes. The infrared spectroscopy showed that metal complex is formed by hydroxyl group. All the complexes showed resistance against Gram negative Eschericia coli and Gram positive Staphylococcus aureus bacteria. The zone of inhibition for cadmium amoxicillin against Escherichia coli and Staphylococcus aureus was 14 mm and 13 mm respectively. Zone of inhibition measured for zinc amoxicillin against Staphylococcus aureus was 11 mm which is minimum as compared with other complexes. Cadmium amoxicillin showed maximum antibacterial activity against both strain Staphylococcus aureus and Eschericia coli. Therefore it is concluded that cadmium amoxicillin, nickel amoxicillin dihydrate and zinc amoxicillin complexes could be served as antibacterial agents.