Department of Chemistry

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Browsing Department of Chemistry by Author "Ferhat Mehmood"

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    Ethnopharmacological studies on phytochemicals obtained from skimmia laureola (dc.) Zucc. Ex walp. Of Pakistan
    (BIOLOGIA (PAKISTAN), 2013) Ferhat Mehmood; Zaheer-Ud-Din Khan; Qurat Ul Ain Syed; Zahida Perveen; Ayesha Moeyuddin
    A detailed study regarding total antioxidant capacity (TAC), radical scavenging and antimicrobial effects of the essential oils from Skimmia laureola leaves (SL), stem (SS) and roots (SR) were investigated. Essential oils obtained by steam distillation process were subjected to various assays to determine antioxidant capacity. TPC values were found to be 9.07, 20.90 and 71.95 mg/L gallic acid equivalent and 4.08, 22.96 and 329 mg/L quercetin equivalent for SL, SR and SS, respectively. A significant correlation between the percent inhibition of 2,2’-azinobis(3-ethylbenzothiazoline-6-sulpohonic acid) (ABTS) radical cation and the amount of essential oils viz R2 = 0.9971, 0.9851 and 0.996 for SS, SL and SR respectively. The percent superoxide anion radical scavenging activity was found to be 51.75, 45.37and 56.5 percent for SL, SR and SS samples, respectively. The reducing power in terms of ferric reducing antioxidant power (FRAP) values were found to be 0.114, 14.33 and 1.2. mM FeSO4 for SL, SR and SS respectively. All samples exhibited good metal chelating activities. The percent inhibition of the complex formation was found to be 80.37, 44.35 and 25.96 for SL, SR and SS respectively. The oils showed antimicrobial activities comparable to chloramphenicol. The data obtained from oils demonstrate the powerful antioxidative, radical scavenging and antimicrobial properties of the plant.