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Browsing BS by Author "ADEEBA ASLAM"

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    Prevalence of pulmonary and extra-pulmonary tuberculosis in patients of the lahore region
    (UMT Lahore, 2023) ADEEBA ASLAM; RIDA ATHER; SUNDAS AROOJ AFSHAN
    Tuberculosis disease is caused by Mycobacterium tuberculosis, a microorganism first discovered by Robert Koch. This bacterium has the ability to interfere the normal functioning of immune system. It causes pulmonary and extra pulmonary Tuberculosis in infected persons. For the Diagnosis of Tuberculosis, different methods are used such as Acid-fast staining, tuberculin skin test, polymerase chain reaction and culture. Mycobacterium tuberculosis has evolved. Mycobacterium tuberculosis complex includes many species that cause disease such as Mycobacterium tuberculosis causes Tuberculosis in humans, Mycobacterium africanum causes TB in African regions only while in domestic animals: Tuberculosis is caused by Mycobacterium caprae, Mycobacterium bovis, etc. In Pakistan, limited data is present on the prevalence of mutated rpoB genes, so Xpert M. tuberculosis/RIF assay is used to study these mutations. Correct detection of mutated rpoB genes is important as it is required for the correct diagnosis of resistance of RIF in M. tuberculosis strains. The recent study is based on 200 patients out of which 173 patients are clinically diagnosed. It is aimed to examine the Prevalence of Pulmonary and Extra-Pulmonary Tuberculosis in Patients of Lahore region. Different tests were performed on the samples taken from 200 patients which include sputum test, GeneXpert test were performed. Furthermore, for the purpose of statistical analysis different software were used in this study which include ANOVA, Chi-square, Graphpad prism, etc. were used. According to study males (age group: 51-60) were significantly infected with Tuberculosis. As well as patients of age group 51-60 were more likely to have pulmonary tuberculosis with significant P-value of 0.016. But regarding to gender WHO and MDR programs are ensuring the prevention and control of TB by applying some strategies to control multi-drug resistance applying the DOT Plus strategies.