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Browsing MS by Author "ALI JAAN"

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    Study of newly synthesized cationic surfactants for drug interaction and antimicrobial activity
    (UMT, Lhr, 2018) ALI JAAN
    Two pyridinium based new cationic surfactants which have synthesized with a different group position of methyl on a pyridine ring and a same long alkyl chain of hydrocarbons have been successfully synthesized. The synthesis involved the reaction of 2-methylpyridine with alkyl halide in a toluene solvent. The synthesized compounds give 90%-95% yield. A tail of those pyridinium based surfactant, directly attached to the pyridinium nitrogen in the presence of bromine which remains present in solution as a counter anion. The newly synthesized cationic surfactants are confirmed by the Fourier Transform Infrared spectroscopy FTIR. The confirmation peaks for sample A1 is 1170 cm-1 and 1209 cm-1 for sample A2. The proton and carbon nuclear magnetic resonance spectroscopy 1H NMR, 13C NMR was also carried out. The C-N confirmation shift can be seen at 58.56 and 61.98 for sample A1 and sample A2 respectively. The spectroscopy and conductometry techniques were used to study the micellization behavior of cationic surfactants. The synthesized compounds showed a critical micelle concentration (CMC) in a very low value range (0.111 mM to 0.125 mM), which actually proves the best surface acting ability of the synthesized compounds. Both compounds efficiently showed an antibacterial activity against the different classes of pathogen bacteria with the various inhibition zones (3 mm to 6mm). The change in Gibb’s free energy (ΔG) were also calculated from their binding constant (K) for sample A1 and sample A2 14.5 KJ/mol and 25.3 KJ/mol respectively. The samples showed the spontaneity of the reactions while interacting with drug molecules. A successful drug interaction proved the efficient bio-availability of drug due to the best incorporation of drug molecules with the aggregated monomers of surfactant (a micelle).