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Browsing School of Science (SSC) by Author "Amna Khalid"

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    Hepatoprotective effect of cichorium intybus linn(kasni) seeds extracts on carbon tetrachloride induced liver damage in albino mice
    (University of Management and Technolog, 2017) Amna Khalid
    Present investigations were carried out to establish the medicinal value of Cichorium intybus Linn. synonym chicory,. This medicinal plant belongs to the family Asteraceae. The objective of this research was to evaluate the hepatoprotective effect of Cichorium intybus on the damaged liver of Swiss Albino mice by the induction of CCl4. The aqueous alcoholic seeds extract of chicory were provided orally in different doses 100 mg/kg, 250 mg/kg and 500mg/kg to albino mice divided into groups, each group had six mice. The dose was given for seven days and on the very next day of last dose followed by CCl4, a healthy mouse of each group was sacrificed, blood was taken in EDTA tubes and liver was stored in formalin solution. ALTs kits were used to test the blood of animals. It was observed that the levels of serum enzymes including Serum Glutamate pyruvate transaminase (SGPT), Alkaline Phosphate (ALKP), Serum Glutamate Oxaloacetate Transaminase (SGOT), and bilirubin were decreased. For comparative analysis silymarin was used as a standard drug. The results clearly revealed that , the values of SGPT, SGOT, ALKP and Bilirubin were 56.05, 58.25, 139.11, 0.81 for negative control group, 57.06, 88.28, 137.85, 0.38 for positive control group, 107.89, 119.54, 158.36, 1.43 for C. intybus group (100 mg/kg), 91.44, 92.67, 189.41, 1.05 for C.intybus group (250 mg/kg) and 80.21, 74.29, 163.24, 0.78 for C. intybus group (500 mg/kg) repectively. The histopathological studies of mice liver were also carried out . This study showed that the plant seeds extract of 500mg/kg showed more positive effect rather than 250 mg/kg and 100 mg/kg against CCl4 induced liverdamage. The results infered that the aqueous alcoholic seeds extract of Cichorium intybus showed excellent hepatoprotective effect against CCl4 induced liver damage in albino mice. This study proved that Cichorium intybus acts as an indigenous plant which is highly effective for the liver problems. Further work on Cichorium intybus is needed to isolate biological and chemical components from the seeds and to evaluate the biological activity of refined constituents