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Browsing School of Science (SSC) by Author "Abdul Razzaq Murtza"

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    Identification and analysis of under lying mechanism of liver cirrhosis in local population of Gujranwala, Pakistan
    (University of Management and Technolog, 2017) Abdul Razzaq Murtza
    Largest body organ of human is liver. It lie in the upper right quadrant of body and provide double blood supply. A health liver consist of 202x1023 per milligram cell that categorized as parenchyma cell, kupffer cell, hepatic stellate cell, Pit cell. According to a estimate liver perform 500 different kind of function, Such as removing contaminate from blood, convert nutrient from food, storing minerals vitamins, regulating blood clothing, producing protein enzyme and fight against infection, but due to drug, viral or some other infection cause liver injury or cell death as a result of it liver fibrosis and cirrhosis occur. Cirrhosis is irreversible and end stage of liver disease, it is mostly occur in 5th and 6th decade of life and according to a estimate 170 million people are infected which is 3% of global population. In liver cirrhosis normal cell of liver replace by nodule like structure, which harden the liver. Cirrhotic patients become very sensitive for multiple complications. Portal hypertension and ascites are commonest complication in liver cirrhosis patients. The virus infected patient's analysis qualitative by using PCR. Blood analysis of the patients has done by performing liver function test. Fibro scan has used for measuring the liver stiffness. This study has conducted on 228 patients in which 121 were male and 107 female. The most of the patients infected by HCV that were 196 85.96% that categorized into cirrhotic 78.04% and non-cirrhotic 65.71% , HBV infected patients were 38 16.66% in which 19 15.44% cirrhotic and 19 18.09% were non cirrhotic respectively. HCV/HBV co-infected patients were 15 6.57% in which cirrhotic 6 2.63% , non-cirrhotic 9 8.57%. The patients infected by genotype 3 were more in number then 4. When AST/ALT ratio were observed for these cirrhotic and non-cirrhotic patients it is revealed that it is higher in cirrhotic patients then non-cirrhotic. In cirrhotic patients a number of complication rise in which ascites, splenomegaly, diabetes mellitus and complication were most prominent. A number of risk factor were noted in these patients but dentist was most common risk factor in cirrhotic patients. We concluded that HCV infection is the major risk factor for cirrhosis in our patients. HCV genotype 3 accounts major HCV infection in our study and it is the most frequent genotype among HCV-Positive . A strong association between HCV, GT-3 infection and HCC was also found in our study. The result of my study also shows that cirrhotic patients had significantly shorter life than non-cirrhotic patients.