FORMULATION & CHARACTERIZATION OF FUNCTIONAL LOZENGES USING SOLVENT DISPLACEMENT METHOD
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Date
2024
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Publisher
UMT.Lahore
Abstract
General gastrointestinal (GI) issues like nausea and vomiting can occur due to several
emetic stimuli when hazardous chemicals, medicines, germs, viruses, or fungus enters
the body through the GI tract or parenteral pathways. The prescription of anti-emetic
pharmaceuticals is deemed unnecessary, hence, is avoided. The use of complementary
and alternative medicine (CAM) has been a practice for eliminating nausea and
vomiting either of motion or morning sickness origin. Some of the ingredients used in
these herbal remedies include ginger, lemon, chamomile, rosemary and peppermint.
However, their incorporation in one product is a challenge. Lozenges are a good
medium for that. These are palatable, easier to use and justifiable in terms of safety
concerns. To enhance the bioavailability of these components and for the increase in
their dissolution rate, dispersion techniques have proven more efficient than any other
method. The solvent displacement method of dispersions, which is best suitable for
plant products, is used in this study to formulate functional lozenges containing the
dispersions of ginger, lemon and mint for the relief of nausea and vomiting symptoms.