In silico analysis of NF1 network in cutaneous melanoma
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Date
2020
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UMT Lahore
Abstract
Cutaneous melanoma is a type of cancer formed by transformation of melanocytes in malignant manner. This skin cancer varies among same age of people with same stage. This disease is increasing day by day in all over the world. Mutations in NF1 causes major dysregulation of RAS/RAF/MAPK pathways which inhibits apoptosis and proliferation of melanocytes. For understanding major onco-proteins role in cancer, it is possible by network biology approach. NF1 protein-protein interaction network was extracted and its cluster was formed on STRING database version 11.0. Enrichment analysis were done on ShinyGo version 0.61. Hub proteins were identified on CytoHubba of Cytoscape plugin version 3.4. Mutations of hub proteins were analyzed on cbioportal. Thirty hub proteins showed novel mutations in 181 samples of cutaneous melanoma. Gene alteration frequency was 50 %. These hub proteins showed their role in cutaneous melanoma.