Genetic variants in FGFR2 and TNRC9 genes are associated with breast cancer risk in Pakistani women.

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dc.contributor.authorAfzal, Mohammad Naveed
dc.date.accessioned2018-10-09T07:38:52Z
dc.date.available2018-10-09T07:38:52Z
dc.date.issued2016-08-18
dc.description.abstractSingle nucleotide polymorphisms (SNPs) lead to genetic differences in breast cancer (BC) susceptibility among women from different ethnicities. The present study aimed at investigating the involvement of SNPs of three genes, including fibroblast growth factor receptor 2 (FGFR2), trinucleotide-repeat-containing 9 (TNRC9) and mitogen-activated protein kinase kinase kinase 1 (MAP3K1), as risk factors for the development of BC. A case control study (90 100 cases; 90 100 controls) was performed to evaluate five genetic variants of three genes, including FGFR2 (SNPs: rs1219648, rs2981582), TNRC9 (SNPs: rs8051542, rs3803662) and MAP3K1 (SNP: rs889312) as BC risk factors in Pakistani women. Significant associations were observed between BC risk and two SNPs of FGFR2 [rs2981582 (P=0.005), rs1219648 (P=9.08e 006)] and one SNP of TNRC9 [rs3803662) (P=0.012)] in Pakistani women. On examining the different interactions of these SNPs with various clinicopathological characteristics, all three associated genetic variants, rs2981582 rs1219648 and rs3803662, exhibited a greater predisposition to sporadic, in comparison to familial, BC. Furthermore, there was an increased effect of BC risk between haplotype combinations of the two SNPs of FGFR2 (rs2981582 and rs1219648) in Pakistani women. The results of the present study suggest that variants of FGFR2 and TNRC9 may contribute to the genetic susceptibility of BC in Pakistani women.en_US
dc.identifier.citationMazhar, A., Jamil, F., Bashir, Q., Ahmad, M. S., Masood, M., Tanvir, I., Rashid, N., Waheed, A., Afzal, M. N., & Tariq, M. A. (2016). Genetic variants in FGFR2 and TNRC9 genes are associated with breast cancer risk in Pakistani women. Molecular Medicine Reports. (Mohammad Naveed Afzal (SHS), JCR LISTED (IF:1:56))en_US
dc.identifier.urihttps://escholar.umt.edu.pk/handle/123456789/3184
dc.language.isoenen_US
dc.publisherMolecular Medicine Reports.en_US
dc.subjectHealth Scienceen_US
dc.titleGenetic variants in FGFR2 and TNRC9 genes are associated with breast cancer risk in Pakistani women.en_US
dc.typeArticleen_US
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