Comparative analysis of factors associated with initiation and progression of CVST
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Date
2023
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UMT, Lhr
Abstract
Cerebral venous sinus thrombosis is a posterior and cavities condition that forms due to the formation of clots in the veins of the bloodstream, specifically in the area of the paranasal sinuses. It can be diagnosed in several ways, including a physical examination and medical history. Various symptoms such as headaches, seizures, vision disturbances, etc. They appear when the effects of caffeine are related to an inadequate metabolism and the cause of this disease increases due to the constriction of the veins that facilitate the increase in blood pressure and the faster formation of clots in them. areas. In this research, different computational methods were used to identify structural and functional changes associated with a change in the wild-type sequence. 38 of 176 nsSNPs in the human CYP1A2 gene were predicted by a combination of computational methods. As functional variables. To look for possible connections with pathogenicity, functional nsSNPs were further examined. The result was that 18 nsSNPs were predicted as pathogenic, among which variants G73R, G73W, R108Q, R108W, E168K, E346K, R431W, F432S, and R456H were also found to be associated with pathogenicity. These results provide new insights into the structure-function association in CYP1A2, CVST and other CYPs and can be taken into account when planning experimental investigations. To fully understand the links and causes of diseases, it is necessary to use more sophisticated methods.