Relationship of ABO blood groups with metabolic syndrome in a population in northern lahore
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Date
2024
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UMT, Lhr
Abstract
Background and Objectives: Metabolic syndrome (MetS) has high prevalence in Pakistan, however its relationship with ABO blood groups has not been investigated in Pakistani population. The aim of this study was to find out the prevalence of MetS in a population of North of Lahore and Okara and determine its relationship with ABO blood groups. Methodology: A total of 290 apparently healthy adults (20-70 years old) were enrolled in this cross-sectional study with informed consent. The recruitment was started on August 7,2022 and completed by October 25,2023. A cohort of 58 adults was also recruited from Okara for comparison purposes. Pregnant females and individuals suffering from chronic diseases were excluded from the study. Demographic information was obtained from recruited subjects using a structured questionnaire. Waist circumference was determined using a measuring tape, while blood pressure was assessed using a sphygmomanometer. Serum concentrations of fasting glucose, triglycerides and high-density lipoprotein cholesterol were monitored using available kits. Similarly, ABO blood groups were determined by using a kit method. The data were entered in the SPSS, version 23 and various tests such as Chi square test, independent sample t test and logistic regression were employed for statistical analysis. Results: The mean ± SD age of subjects was 35.4 ± 11.8 years. The prevalence of MetS as per Harmonized Criteria was found to be 64% in this population from North of Lahore while prevalence of MetS in population of Okara was 45%. The percentage values of abdominal obesity, hypertriglyceridemia, low-HDL cholesterol, hyperglycemia and hypertension were 73%, 63%, 81%, 41% and 42%, respectively. Regarding income, the adjusted odds of developing MetS was 7.53 times higher in subjects having monthly household income in the range PKR 50,001-80,000 [AOR = 7.53; 95% CI (1.34 – 42.3)]. Regarding use of smokeless tobacco, those subjects who were non-consumers had 83% less odds of having MetS compared to active consumers [AOR = 0.17; 95% CI (0.04 – 0.67)]. The blood group B was the most common (42.9%), followed by blood group O (27.6%) and A (17.9%), while the AB lood group was least frequent (11.4%). There was no statistically significant association between ABO blood groups with MetS. Conclusion: The prevalence of MetS was 64% in population of North of Lahore. There was no association of various ABO blood groups with MetS in this population.