In-silico identification of potential phytochemicals against selected proteins involved in the pancreatic ductal adenocarcinoma
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Date
2023-08-11
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Publisher
UMT Lahore
Abstract
Due to the highly malignant nature of Pancreatic cancer, it is considered as one of the deadliest cancers. Only 5% of patients survive this gastrointestinal malignancy. This cancer has been diagnosed at later stages, mostly 90% spread and metastasized. There is a tiring need to study the underlying mechanism responsible for progression of the disease. There are many proteins that overexpress during this disease. The proteins which were taken into consideration in this study are LIF, NEK, PPP1CA, KLK8. Common mechanisms shared by these proteins are cell proliferation, differentiation, invasiveness, and metastasis. Existing options include surgical resection of infected areas, chemotherapeutic drugs, some combinational therapies as well. There are many drugs which are in phase I and II, some of which are showing better results and some need deeper consideration. The selected proteins were considered as targets and against them potential anti-cancer drugs have been identified. These drugs will inhibit the function of these proteins through which the cancer progresses. Piroxicam was identified as a novel anti-LIF and anti-KLK8 drug. Boeravinone B was identified as a potential inhibitor for NEK7 and PPP1CA.