Study of antimicrobial activity and molecular docking of phytochemicals in OLEA EUROPAEA

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dc.contributor.authorFASIHA ARIF
dc.date.accessioned2025-11-17T19:35:33Z
dc.date.available2025-11-17T19:35:33Z
dc.date.issued2019
dc.description.abstractBacterial infections have appeared as a serious warning in population. By increase of synthetic antibiotics resistance, medicinal plants have used to treat such infections. In this research work, antimicrobial activity of Olea europaea parts was checked against bacterial and fungal strains. Agar disc diffusion, well diffusion and agar dilution methods was used for estimation its antimicrobial efficacy. Antioxidant effect of its all extracts was estimated by DPPH method. In silico the ADMET properties of phytochemicals of Olea europaea was checked by bioinformatics tools SwissADME and Protox. Only 39 compounds obeyed the ADMET properties and expressed the drug like similarities. These phytochemicals were docked with DNA gyrase subunit b from E.coli, FtsZ from B.subtilis and LpxC from P.aeruginosa via AutoDock Vina and binding affinities were evaluated. This study demonstrated that methanol and ethanol extract inhibited the all bacterial strains while they exposed no inhibition against fungal strain. Water extract did not show any inhibition. In agar dilution method inhibitory effect was observed by ethanol stem against P.aeruginosa and E.coli and ethanol leaves against P.aeruginosa. Antioxidant activity results exhibited that all extract exposed the positive results except methanol roots. Moreover, water leaves expressed the maximum antioxidant activity and ethanol roots showed minimum antioxidant efficacy. Computational study demonstrated that only all of the phytochemicals have inhibitory effect against selected bacterial targets by different binding affinities. The ADMET properties of Olea europaea phytochemicals and their binding to the bacterial proteins elucidated that they have effective inhibitory potential.
dc.identifier.urihttps://escholar.umt.edu.pk/handle/123456789/10287
dc.language.isoen
dc.publisherUMT Lahore
dc.titleStudy of antimicrobial activity and molecular docking of phytochemicals in OLEA EUROPAEA
dc.typeThesis
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