Evaluation of antimicrobial and anti-diabetic potential of parthenium hysterophorus

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dc.contributor.authorNOOREEN ASGHAR
dc.date.accessioned2025-12-03T12:55:04Z
dc.date.available2025-12-03T12:55:04Z
dc.date.issued2018
dc.description.abstractParthenium hysterophorus is an aggressive and harmful weed but have some beneficial features. It produces a diverse range of bioactive molecules such as flavonoid, terpenoids, tannins, amino sugars and other phenolic derivatives which make it active against various infections. The aim of current work was to evaluate in vitro anti-microbial and anti-diabetic activities, using P. hysterophorus organic extract concentrations. To evaluate the anti-bacterial and anti-fungal potential, different concentrations of methanolic and wax extracts of P. hysterophorus were used against bacterial strains such as E.coli, K.leb, S.pseduo, S.Aureus and fungal strains S.cerevisiae and C.albicans. Gentamycin and Nystatin were used as positive control for bacteria and fungi respectively. All concentrations were active against all pathogenic organisms. Varied zones of inhibition were observed due to bioactive constituents that disperse at different rates. Range of inhibition zones 11- 21mm in diameter were recorded using methanolic extract whereas zones of 7-18mm indiameter were observed using wax extract for bacterial strains. For fungal strains range of inhibition zones by using methanolic extract were 10-20mm in diameter and 8-15mm in diameter with wax extract. In case of anti-diabetic potential, acarbose was used as standard to inhibit the activity of alpha-amylase enzyme. Using different concentrations of P. hysterophorus extracts, inhibition percentage was observed. For methanolic and wax extracts, the inhibition ranges from 26.02% to 76.20% and 22.08 to 73.85% respectively. These inhibitions were closely associated with that of acarbose inhibition percentage ranged from 33.00% to 82.20%. It is concluded that P. hysterophorus methanolic extract exhibited highest anti-microbial and anti-diabetic potential compared to its wax extract and this potential increased as the concentration of extracts increased. However, Zones of inhibition and percentage of inhibition were less than standard drugs.
dc.identifier.urihttps://escholar.umt.edu.pk/handle/123456789/14869
dc.language.isoen
dc.publisherUMT, Lhr
dc.titleEvaluation of antimicrobial and anti-diabetic potential of parthenium hysterophorus
dc.typeThesis
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