Study of HLA polymorphism (HLA-B and HLA-C) in local population

Simple item page
dc.contributor.authorMAHAM ASHFAQ
dc.date.accessioned2025-11-17T16:33:11Z
dc.date.available2025-11-17T16:33:11Z
dc.date.issued2019
dc.description.abstractHuman leukocyte antigen (HLA) is involved in generating immune response whenever any foreign tissue is implanted in human body. HLA consists of two classes known as class I and class II. HLA-B and HLA-C loci are situated within class I. Matching of HLA-B and HLA-C loci among patient and donor is necessary for organ transplantation. Currently, genes of HLA are being identified on the basis of their DNA sequences with the use of molecular techniques. Taking into consideration the significance of HLA genes in transplantation, we aimed to find out the prevalence and association of HLA-B and HLA-C alleles within patients as well as donors, blood groups, ethnic groups, age groups and gender in local population. Blood was extracted from patients and donors intravenously and genomic DNA was isolated from blood by using DNAzol reagent. By analyzing the frequency of HLA-B and HLA-C alleles among people, we found diverse results. In different age and blood groups, allele 8 was observed more frequent in HLA-B locus and allele 7 was observed more frequent in HLA-C locus. Similarly, in case of locality, gender and patient/donor allele 8 of HLA-B and allele 7 of HLA-C were dominant. Based on our study it has been analysed that a better HLA-match is associated with better engraftment and survival.This survival can be achieved through exact matching of HLA alleles among patient and donor
dc.identifier.urihttps://escholar.umt.edu.pk/handle/123456789/10219
dc.language.isoen
dc.publisherUMT Lahore
dc.titleStudy of HLA polymorphism (HLA-B and HLA-C) in local population
dc.typeThesis
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Study of hla polymorphism (hla-b and hla-c) in local population.docx
Size:
857.32 KB
Format:
Microsoft Word XML
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
2019