Antidiabetic and hypolipidemic activity of euphorbia prostrata
No Thumbnail Available
Date
2018
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
UMT, Lhr
Abstract
In past medicinal plants had been used for the treatment of diabetes and hyperlipidemia because of their antidiabetic and hypolipidemic properties but there was no scientific evidence of it. Aim of present study was to investigate the antidiabetic and hypolipidemic activities of Euphorbia prostrata. It is a small, prostrate, green annual herb and belongs to family Euphorbiaceae. It is applicable for the treatment of wound healing, bleeding hemorrhoids, breathing disorders, tumors, severe diarrhea (dysentery), gonorrhea, and digestive problems etc. Many phytochemicals isolated from this plant such as phenolic acids like gallic acid, ellagic acid ,flavonoids like apigenin, quercetin, luteolin (and their glucosides) and tannins that were responsible for antidiabetic and hypolipidemic activities. Acarbose used as positive control that resists the activity of alpha amylase enzyme. For methanolic extracts of plant inhibition percentages ranges from22.02% to 76.20% against different concentrations that were close to the acarbose inhibition percentages ranged from 33.00% to 82.20%.Orlistat used as positive control that resist the activity of lipase enzyme. For methanolic extracts of plant inhibition percentages ranges from 35.88% to 82.08% against different concentrations that were close to the orlistat inhibition percentages ranged from 41.23% to 87.59%. It was estimated by statistical analysis that IC50 value of acarbose and orlistat was 0.023 and 0.017 and that of plant extracts was 0.029 and 0.022 for antidiabetic and hypolipidemic activity. Results showed that with the increase of concentrations of standards and plant extracts inhibition percentages also increases.