Compositional analysis of non polar extract of melia azedarach
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Date
2015
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Umt, Lahore
Abstract
Medicinal plants are widely used by the traditional practitioners to cure different diseases due to their world-wide availability and fewer side effects. Melia azedarach L. belongs to the family Meliaceae which is a family of highly significant medicinal plants. Traditionally, different parts such as leaf, flower, seed, fruit, and young branches of M. azedarach have been used for the treatment of malaria, diabetes, purgative, cough, skin disease, and many more. Experiment and clinical studies prove that it has antimicrobial, antioxidant, anti-inflammatory, cardioprotective, anticancer, analgestic, antiulcer, antipyretic, antiplasmodial and male contraceptive properties. Thus the aim of this study was to explore the chemical profile of non-polar extract of M. azedarach leaves through GC-MS analysis, as well as to check the antimicrobial activity of this plant against different bacterial strain by using agar diffusion method. The identification of phytochemical compounds was carried out by comparing molecular ion peak, base peak, and fragmentation pattern. GC-MS analysis of hexane extract of M. azedarach showed a highly complex profile, containing ketones, ethers, fatty acid derivatives, methyl esters, 1,3-dipalmitate, 7,8-dihydrocarpesterol, and 2-Undecanol. The results of antibacterial activity of hexane extract showed that M. azedarach possessed mild resistance against the bacterial infection. This study also indicated that hexane extract of M. azedarach was more potent against the Gram-positive than the Gram-negative bacteria. This study will be useful to explore the pharmacological and biosynthetic activity of plants further.