Analysis of phytochemicals as inhibitors against neuraminidase (NA) from influenza virus a H1N1 (PDM09) using molecular docking.
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Date
2019
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UMT Lahore
Abstract
Influenza virus commonly known as swine flu is well known virus which is infecting large number of population globally. It becomes threat to human lives. Phytochemicals are used to cope virus related, and other infectious diseases in people. The purpose of study is base on to known about phytochemicals which is used to treat influenza virus A Neuraminidase (pdm09). Total 105 phytochemicals were docked from which fourteen have binding affinity -6.3kcal/mol or more. Out of these fourteen phytochemicals only three showed good inhibitory effect on influenza A virus Neuraminidase. This study was based on computer based drug development software against Neuraminidase protein of Human Influenza A virus (pdm09). Molecular Docking is used to calculate binding affinities of phytochemicals.