ANTI-HYPERGLYCEMIC EFFECT OF ARGYROLOBIUM ROSEUM (Cambess.) jaub. & spach
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Date
2025
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UMT, Lahore
Abstract
Diabetes mellitus is slowly poisoning disease and becomes a matter of concern from last decade because of its prevalence. In this regard a research plan designed to address the global disease. A wild herb testing against the disease with STZ model. ARGYROLOBIUM ROSEUM (CAMBESS.) Jaub. & Spach is annual wild herb grow in sandy rock places. It is commonly found in the Pakistani hilly areas in February. It is flowering and fruiting plant belongs to family papiolionaceae. Ethanolic extract
prepared against the plant for in vivo testing (rats) against STZ and in vitro testing (GC MS). An ethanolic extract prepared from dried herb. Some extract again fractionated in ethyl acetate n hexane aqueous extracts for GC MS. For in vivo study take Sprague Dawely rats 4(n=5) and induced diabetes with STZ. Before that acute toxicity testing and observe no sign of toxicity. The in vivo model planned for 28 days. The standard used against is metformin. After testing all rats sacrificed and sample took for biochemical markers (HbA1c, ALT AST, APL, urea, and creatinine).
Histopathological study also conducts. In results plant decrease diabetes and Beta cell neogenesis. Biochemical markers not show any significant change compare to normal. Oral glucose tolerance test poor show sustainability. Ethyl acetate extract show less hypoglycemic activity. GC MS show mostly phenols and fatty acid ester.