Synthesis & Characterization of Copper (II) Metal Organic Framework@Fe3O4 for Excellent Antibacterial Activity
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Date
2022
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Publisher
UMT, Lhr
Abstract
Metal-organic frameworks (MOFs) can be used as antibacterial agents because of their effective antibacterial properties. In this research, nanocomposites of copper(II)
based MOFs with iron oxide [Cu-MOF@Fe3O4] were prepared via a simple hydrothermal route. X-ray analysis reveal the crystallinity of the structure while FTIR
analysis confirm the presence of Cu-based MOFs functional group. SEM images of Cu-MOF reveal irregular clusters of cubic particles that fused together to fill porosity
by Fe3O4 nanoparticles in Cu-MOF@Fe3O4. The elemental composition was confirmed by EDX analysis. The antibacterial activities of the Cu-MOF and Cu
MOF@Fe3O4 against Escherichia coli (E. coli) and Bacillus subtilis (B. subtilis) were assessed using the minimum inhibitory concentration (MIC) and zone of inhibition
assays. The nanocomposites outperformed Cu-MOF, commercial copper nanoparticles, and pure ligands in inhibiting the bacteria. It is because of its potential to
release Cu2+ ions slowly and prolonged in biocidal concentration. The nanocomposites [Cu-MOF@Fe3O4] also showed higher antibacterial performance against Escherichia coli (E. coli) as compared with Bacillus subtilis (B. subtilis).