School of Sciences

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Browsing School of Sciences by Subject "bacteriophage, endolysins, lysogenic, lytic, phage therapy"

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    Bacteriophages: an overview of the control strategies against multiple bacterial infections in different fields
    (Journal of basic microbiology, 2018) Mohsin Jamal; Sayed M. A. U. S. Bukhari; Saadia Andleeb; Muhammad Ali; Sana Raza; Muhammad A. Nawaz; Tahir Hussain; Sadeeq u. Rahman; Syed S. A. Shah
    Bacteriophages (phages/viruses) need host bacteria to replicate and propagate. Primarily,abacteriophagecontainsahead/capsidtoencapsidatethegeneticmaterial. Somephagescontaintails.Phagesencodeendolysinstohydrolyzebacterialcellwall. The two main classes of phages are lytic or virulent and lysogenic or temperate. In comparison with antibiotics, to deal with bacterial infections, phage therapy is thought to be more effective. In 1921, the use of phages against bacterial infections was first demonstrated. Later on, in humans, phage therapy was used to treat skin infections caused by Pseudomonas species. Furthermore, phages were successfully employed against infections in animals – calves, lambs, and pigs infected with Escherichiacoli.Inagriculture,forinstance,phageshavesuccessfullybeenusede.g., Appleblossominfection,causedbyErwiniaamylovora,waseffectivelycateredwith the use of bacteriophages. Bacteriophages were also used to control E. coli, Salmonella, Listeria, and Campylobacter contamination in food. Comparatively, phage display is a recently discovered technology, whereby, bacteriophages play a significant role. This review is an effort to collect almost recent and relevant information regarding applications and complications associated with the use of bacteriophages.