(UNIVERSITY OF MANAGEMENT AND TECHNOLOGY, 2015) Ata Ur Rehman
The molecules comprising azomethine group are famous to possess biological activities. In the present work, the synthesis of N'-Substitutedbenzylidene-2-(2,4-dimethylphenoxy) acetohydrazide (5a-d) has been performed using 2,4-Dimethylphenol(1) as precursor. The molecule 1, was transformed into ethyl 2-(2,4-dimethylphenoxy)acetate (2) on refluxing with ethyl 2-bromoacetate in ethanol medium in the presence of base KOH. Ethyl ester 2, was refluxed with hydrated hydrazine (80%) in ethanol medium to produce 2-(2,4-dimethylphenoxy) acetohydrazide (3). The target molecules 5a-d, were manufactured by stirring 3 with phenyl/aryl carboxaldehyde (4a-d) in methanol medium in the presence of glacial acetic acid. The synthesized molecules were characterized by physical spectral data and estimated for antibacterial and anti-enzymatic activities.