Browsing by Author "Samera Ashraf"

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    IN SILICO CHARACTERIZATION OF SIX MYOSIN XI PROTEINS (XI-H, XI-I, XI-J XI-K, XI-1 XI-2) IN ARABIDOPSIS THALIANA
    (University of Management and Technology, 2017) Samera Ashraf
    Organelle movement in plants cells is extremely dynamic and is acto-myos independent process. Myosins belong to a super family of molecular motor proteins which are present probably in all eukaryotic cells. These proteins are involved in trafficking of organelles, including endoplasmic reticulum (ER), mitochondria, peroxisomes, Golgi stacks, and endomembrane vesicles. These proteins bind with ATP, hydrolyze it to generate force and movement along with actin filaments. This movement is obligatory to carronet various cellular functions. Cell movement, muscular contraction, cytokinesis, membrane trafficking, and signal transduction are driven by myosins that move unidirectional along actin filaments. The present study aims at the analysis of physio-chemical properties of six myosin XI (XI-H, XI-I, XI-J XI-K, XI-1, and XI-2), their functions, binding sites, sub cellular locations, secondary and tertiary structures prediction. Phylogenetic analysis, molecular simulation and molecular docking will be conducted through using different bioinformatics tools to study the characteristics of these proteins.