Browsing by Author "QURAT-UL-AIN ABID"

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    Immunomodulatory activity of meloxicam.
    (UMT, Lhr, 2019) QURAT-UL-AIN ABID
    Meloxicam is an enolic acid derivative which is widely used and has well-known anti-inflammatory and analgesic effects. Many new studies have emerged which display the immuno-pharmacological behavior of NSAIDs. The immunomodulatory activity of meloxicam was evaluated in this work by using immunological experimental mice model and estimating tools like cyclophosphamide induced neutropenia assay, delayed type hypersensitivity assay, hemagglutination assay and mice lethality test. Cyclophosphamide induced neutropenia and delayed type hypersensitivity assays were performed to evaluate cell mediated immunity while the other two models were used to evaluate the effect of flurbiprofen on humoral immunity. Meloxicam was administered intraperitoneally into swiss albino mice at the doses of 1 mg/kg, 1.5mg/kg and 2 mg/kg body weight of mice. The drug in all doses decreased the circulating antibodies and did not prevent the mortality induced by a deadly bovine Pasteurella multocida, evaluated by hemagglutination antibody titre and mice lethality test respectively the decrease in skin thickness in delayed type hypersensitivity assay indicated the inability of meloxicam to stimulate the T cells. WBCs and neutrophil count reduction showed lack of meloxicam effectiveness in preventing cyclophosphamide induced neutropenia. In conclusion, meloxicam decreased both humoral and cell mediated immunity in mice.